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. 2018 Oct 11;10(10):2668–2683. doi: 10.18632/aging.101578

Table 1. King-specific gene list.

Gene symbol Full gene name Signal
RFC3 Replication factor C subunit 3 DDR
RFC4 Replication factor C subunit 4 DDR
TOPBP1 DNA topoisomerase 2-binding protein 1 DDR
ATR Serine/threonine-protein kinase ATR DDR
ATM Serine-protein kinase ATM DDR
CHK2 Serine/threonine-protein kinase Chk2 DDR
ERCC1 DNA excision repair protein ERCC-1 NER
BRCA1 Breast cancer type 1 susceptibility protein HR
MCPH1 Microcephalin HR
XRCC3 X-ray repair cross-complementing protein 3 HR
CDK1 Cyclin-dependent kinase 1 HR
HELQ Helicase POLQ-like HR
RMI1 RecQ-mediated genome instability protein 1 HR
GEN1 Flap endonuclease GEN HR
SLX4 Structure specific endonuclease subunit SLX4 HR
RAD54-like DNA repair and recombination protein RAD54-like HR
APLF Aprataxin and PNK-like factor NHEJ
SMARCAL1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 NHEJ
MLH1 DNA mismatch repair protein Mlh1 MMR
MSH4 MutS protein homolog 4 MMR
MGMT Methylated-DNA—protein-cysteine methyltransferase ADR

DDR, DNA damage response; NER, nucleotide excision repair; HR, homologous recombination; NHEJ, non-homologous end-joining; MMR, mismatch repair; ADR, alkylation damage repair. The genes written in bold were used for quantitative PCR analysis in this study.