Table 1. The effect of APP on gene expression of energy metabolism.
| Gene Name | log2 fold | p value | Description | |
| PRKAA1 | 1.46493 | 0.0138586 | protein kinase, AMP-activated, alpha 1 catalytic subunit | SIRT3 production |
| PPARG | -2.7667 | 0.0003537 | peroxisome proliferator-activated receptor gamma | SIRT3 production |
| USP3 | 1.36399 | 0.0352496 | ubiquitin specific peptidase 3 | SIRT3 degradation |
| PSMD3 | -1.9837 | 0.0037322 | 26S proteasome (prosome, macropain) non-ATPase regulatory subunit 3 | SIRT3 degradation |
| ATPAF2 | 2.28485 | 0.0207859 | ATP synthase mitochondrial F1 complex assembly factor 2 | Energy metabolism |
| HMGCR | -0.9487 | 0.0230069 | 3-hydroxy-3-methylglutaryl-CoA reductase | Energy metabolism |
| ACSS2 | 1.47603 | 0.0004182 | acyl-CoA synthetase short-chain family member 2 | Energy metabolism |
| INSR | 0.89617 | 0.0102131 | insulin receptor | Energy metabolism |
| IRS1 | 1.54338 | 0.0389107 | insulin receptor substrate 1 | Energy metabolism |
| MTFR1L | 1.7624 | 0.0326343 | mitochondrial fission regulator 1-like | |
| TOMM20 | 1.29106 | 0.049985 | translocase of outer mitochondrial membrane 20 |
Note: PRKAA1, PPARG, USP3 and PSMD3 are involved in SIRT3 synthesis and metabolism.