Table 3. Univariate and multivariate analyses of prognostic factors for disease-free survival and overall survival in 152 locally advanced rectal cancer patients who underwent chemoradiotherapy as neoadjuvant treatment.

	DFS				OS
	Univariate		Multivariate		Univariate		Multivariate
Variable	RR (95% CI)	P	RR (95% CI)	P	RR (95% CI)	P	RR (95% CI)	P
Sex	2.081(1.146-3.778)	0.216			1.495(0.761-2.935)	0.243
Age	0.978(0.977-1.023)	0.989			1.012(0.985-1.040)	0.384
T stage	0.799(0.186-3.425)	0.762			0.675(0.151-3.015)	0.959
N stage	0.715(0.377-1.354)	0.303			1.016(0.489-2.113)	0.966
LN	1.010(0.960-1.063)	0.704			0.978(0.918-1.042)	0.486
Positive LN	0.971(0.797-1.183)	0.770			0.888(0.583-1.353)	0.580
PNI	1.516(0.465-4.946)	0.490			2.016(0.612-6.644)	0.239
TD	2.856(1.242-6.565)	0.010	2.727(1.183-6.286)	0.019	4.014(1.712-9.411)	0.001	3.084 (1.323–7.190)	0.017
LVI	1.560(0.482-5.047)	0.458			1.123(0.269-4.698)	0.873
Tumor Differentiation	3.147(0.000-5.814)	0.044			2.908(0.001-2.145)	0.235
TRG	1.403(0.554-3.553)	0.475			1.318(0.490-3.547)	0.585
pCR	1.483(0.711-3.094)	0.290			1.198(0.540-2.657)	0.656
TACC3 expression	2.671(1.050-6.793)	0.032	3.140(1.201-8.210)	0.020	2.525(0.888-7.174)	0.072	3.714(1.261-10.93)	0.017
CEA	1.008(1.002-1.015)	0.015	1.008(1.001-1.015)	0.028	1.002(1.012-3.831)	0.049
CA 19-9	1.001(0.998-1.003)	0.021			1.001(0.998-1.004)	0.072
Neo-chemo regime	1.002(0.001-3.180)	0.998			0.348(0.030-3.988)	0.359
Neo-chemo cycles	0.927(0.649-1.323)	0.675			1.113(0.758-1.636)	0.584
Adjuvant chemo	1.038(0.400-2.689)	0.939			0.804(0.273-2.367)	0.692
Adjuvant chemo cycles	0.857(0.750-0.981)	0.023	0.839(0.731-0.962)	0.012	0.828(0.709-0.967)	0.022	0.8143(0.696-0.949)	0.009