Table 2. Stratification analysis of XRCC1 rs25489 C>T polymorphism and combined risk genotypes with neuroblastoma susceptibility.
| Variables | rs25489 (cases/controls) |
OR (95% CI) | P | AOR(95% CI) a | P a | Combined (cases/controls) |
OR (95% CI) | P | AOR (95% CI)a | P a | ||
| CC | CT/TT | 0-1 | 2-3 | |||||||||
| Age, month | ||||||||||||
| ≤18 | 108/233 (27.48/28.69) |
18/72 (4.58/8.87) |
0.54 (0.31-0.95) |
0.032 |
0.54 (0.31-0.95) |
0.032 | 81/235 | 45/70 |
1.87 (1.19-2.93) |
0.007 |
1.87 (1.19-2.93) |
0.007 |
| >18 | 218/403 (55.47/49.63) |
49/104 (12.47/12.81) |
0.87 (0.60-1.27) |
0.473 | 0.87 (0.60-1.27) |
0.469 | 190/364 | 77/143 | 1.03 (0.74-1.43) |
0.852 | 1.03 (0.74-1.43) |
0.851 |
| Gender | ||||||||||||
| Females | 141/262 (35.88/32.27) |
27/80 (6.87/9.85) |
0.63 (0.39-1.02) |
0.058 | 0.63 (0.39-1.02) |
0.058 | 115/252 | 53/90 | 1.29 (0.86-1.93) |
0.217 | 1.28 (0.86-1.93) |
0.227 |
| Males | 185/374 (47.07/46.06) |
40/96 (10.18/11.82) |
0.84 (0.56-1.27) |
0.411 | 0.84 (0.56-1.26) |
0.402 | 156/347 | 69/123 | 1.25 (0.88-1.77) |
0.215 | 1.25 (0.88-1.78) |
0.206 |
| Sites of origin | ||||||||||||
| Adrenal gland | 127/636 (32.31/78.32) |
26/176 (6.62/21.67) |
0.74 (0.47-1.17) |
0.193 | 0.73 (0.47-1.16) |
0.183 | 107/599 | 46/213 | 1.21 (0.83-1.77) |
0.327 | 1.22 (0.83-1.78) |
0.313 |
| Retroperitoneal | 74/636 (18.83/78.32) |
13/176 (3.31/21.67) |
0.64 (0.34-1.17) |
0.146 | 0.64 (0.35-1.18) |
0.151 | 60/599 | 27/213 | 1.27 (0.78-2.05) |
0.337 | 1.27 (0.78-2.05) |
0.332 |
| Mediastinum | 90/636 (22.90/78.32) |
19/176 (4.83/21.67) |
0.76 (0.45-1.29) |
0.310 | 0.75 (0.45-1.27) |
0.282 | 75/599 | 34/213 | 1.28 (0.83-1.97) |
0.273 | 1.28 (0.83-1.98) |
0.265 |
| Others | 27/636 (6.87/78.32) |
9/176 (2.29/21.67) |
1.21 (0.56-2.61) |
0.637 | 1.21 (0.56-2.62) |
0.636 | 23/599 | 13/213 | 1.59 (0.79-3.19) |
0.193 | 1.60 (0.80-3.21) |
0.189 |
| Clinical stages | ||||||||||||
| I+II+4s | 141/636 (35.88/78.32) |
21/176 (5.34/21.67) |
0.54 (0.33-0.88) |
0.013 |
0.53 (0.33-0.87) |
0.011 | 104/599 | 58/213 |
1.57 (1.10-2.24) |
0.014 |
1.56 (1.09-2.23) |
0.015 |
| III+IV | 168/636 (42.75/78.32) |
43/176 (10.94/21.67) |
0.93 (0.64-1.35) |
0.683 | 0.93 (0.64-1.35) |
0.698 | 154/599 | 57/213 | 1.04 (0.74-1.47) |
0.817 | 1.04 (0.74-1.47) |
0.823 |
AOR: adjusted odds ratio; CI: confidence interval. a Adjusted for age and gender in logistic regress models, without the corresponding stratify factor.