. Author manuscript; available in PMC: 2019 Dec 1.

Published in final edited form as: Eur J Haematol. 2018 Oct 9;101(6):798–803. doi: 10.1111/ejh.13173

Table 1:

Effects of HU on haematological parameters

	Age (yrs)	HbF (%)	MCHC (g/dL)	MCV (fl)	RDW (%)	Hb (g/dL)	Hct (%)	Retic (%)	WBC (10⁹/L)	PLT (10⁹/L)
SCA without HU (n=91)	30 ± 11 (16-69)	6.4 ± 4.3 (1.0-21.0)	31.5 ± 1.9 (24.8-34.7)	90.2 ± 9.8 (67.2-109.2)	22.4 ± 3.1 (16.5-33.1)	7.9 ± 1.5 (4.1-11.5)	24.4 ± 4.8 (12.8-36.1)	14.6 ± 7.9 (3.2-46.4)	13.2 ± 3.6 (6.9-24.4)	451 ± 156 (153-793)
SCA with HU including non responders (n=21)	33 ± 9 (22-61)	11.0 ± 8.3 (1.3-26.9) ^*	28.8 ± 2.2 (24.0-33.0) ^*** ^††	111.1 ± 21.0 (84.5-158.8) ^*** ^††	20.1 ± 3.4 (12.6-27.2) ^*	9.0 ± 1.3 (7.1-11.5) ^* ^†	27.8 ± 4.3 (22.3-35.4) ^* ^†	10.3 ±6.0 (1.9-22.9)	11.8 ± 5.6 (5.9-23.8)	396 ± 123 (131-533)
SCA with HU excluding non responders (n=18)	33 ± 9 (22-61)	14.2 ± 7.5 (4.2-26.9) ^***	29.0 ± 2.4 (24.0-33.0) ^*** ^††	115.3 ± 21.3 (84.5-158.8) ^*** ^†††	19.4 ± 3.1 (12.6-25.7) ^**	9.2 ± 1.4 (7.1-11.5) ^* ^†	28.6 ± 4.6 (22.3-35.4) ^* ^†	10.4 ± 6.4 (1.9-22.9)	9.9 ± 4.1 (5.9-16.9)	383 ± 152 (131-533)
SCA with placebo (n=9)	28 ± 3 19-37	8.1 ± 3.6 (5.5-10.6)	31.7 ± 2.3 (27.7-33.6)	91.5 ± 10.9 (76.7-110.8)	22.3 ± 2.7 (19.7-26.8)	6.8 ± 1.4 (5.8-7.8)	20.3 ± 4.1 (17.4-23.2)	19.0 ± 6.2 (14.6-23.4)	15.3 ± 5.8 (11.2-19.4)	308 ± 88 (246-370)

Different from SCA without HU:

p < 0.05;

^**

p < 0.01;

^***

p < 0.001.

Different from SCA with placebo

^†

p < 0.05;

^††

p < 0.01;

^†††

p < 0.001.