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In vitro and In vivo toxicity of MeP-dR, F-dAdo, and F-araA
|
In vitro IC50 (µM) |
In vivo (maximally tolerated dose) |
Total dose (mg/kg) |
|
|---|---|---|---|
| MeP-dR | >100 | 67 mg/kg (3 doses) | 201 |
| F-dAdo | 0.1 to 1 | 20 mg/kg (15 doses) | 300 |
| F-araA/F-araAMP* | 1 to 10 | 100 mg/kg (15 doses) | 1,500 |
In vitro, F-araA; In vivo F-araAMP
