Table 4.

Clinical-MRI relationships with manual lesion volume, denoted as $\widehat{\rho }\left(\mathit{Manual}\right)$, or MIMoSA lesion volume, denoted as $\widehat{\rho }\left(\mathit{MIMoSA}\right)$, was averaged across cross-validation folds. T1 lesion (T1L) volume, T2 lesion (T2L) volume, and the T1L/T2L ratio were correlated separately with Expanded Disability Status Scale (EDSS) score, timed 25-ft walk (T25FW), and disease duration. For each assessment, p-values were calculated and are presented in parentheses beside each measure. The first table presents unadjusted correlations; the second table presents correlations adjusted for sex and age (in years).

Clinical Associations
		EDSS	T25FW	Disease duration
T1L	$\widehat{\rho }\left(\mathit{Manual}\right)$, (p-value)	0.32, (0.26)	−0.07, (0.56)	0.12, (0.54)
	$\widehat{\rho }\left(\mathit{MIMoSA}\right)$, (p-value)	0.34, (0.21)	−0.05, (0.58)	0.29, (0.30)
T2L	$\widehat{\rho }\left(\mathit{Manual}\right)$, (p-value)	0.33, (0.24)	−0.07, (0.55)	0.15, (0.52)
	$\widehat{\rho }\left(\mathit{MIMoSA}\right)$, (p-value)	0.32, (0.23)	−0.08, (0.56)	0.23, (0.37)
T1L/T2L ratio	$\widehat{\rho }\left(\mathit{Manual}\right)$, (p-value)	0.33, (0.22)	0.13, (0.56)	0.06, (0.54)
	$\widehat{\rho }\left(\mathit{MIMoSA}\right)$, (p-value)	0.33, (0.22)	0.18, (0.45)	0.40, (0.12)

Adjusted Clinical Associations
		EDSS	T25FW	Disease duration
T1L	$\widehat{\rho }\left(\mathit{Manual}\right)$, (p-value)	0.36, (0.23)	−0.03, (0.56)	0.08, (0.59)
	$\widehat{\rho }\left(\mathit{MIMoSA}\right)$, (p-value)	0.34, (0.25)	0.04, (0.58)	0.13, (0.53)
T2L	$\widehat{\rho }\left(\mathit{Manual}\right)$, (p-value)	0.38, (0.21)	−0.02, (0.55)	0.10, (0.57)
	$\widehat{\rho }\left(\mathit{MIMoSA}\right)$, (p-value)	0.34, (0.23)	−0.05, (0.58)	0.14, (0.50)
T1L/T2L ratio	$\widehat{\rho }\left(\mathit{Manual}\right)$, (p-value)	0.36, (0.20)	0.16, (0.53)	0.12, (0.51)
	$\widehat{\rho }\left(\mathit{MIMoSA}\right)$, (p-value)	0.30, (0.31)	0.18, (0.46)	0.26, (0.30)