Table 2.

Amplitude of low frequency fluctuations (ALFF) and functional connectivity (FC) in control and pediatric HIV. For each cluster, the coordinates of the peak difference as well as the anatomical location and size (in voxels) are shown.

RS-fmri metric	Brain region	Cluster size	T-scores	Peak MNI coordinates			Control Mean ± SD	HIV Mean ± SD	P value
				X	Y	Z
ALFF	L Middle temporal	36	4.29	−60	−21	−6	1.31 ± 0.25	1.03 ± 0.16	<0.001
	L Precentral	37	3.80	−57	0	33	1.15 ± 0.20	0.91 ± 0.13	<0.001
	L Postcentral	79	5.22	−39	−27	42	1.28 ± 0.27	0.99 ± 0.18	<0.001
FC-Seed region-1	R Inferior Parietal	43	3.9	63	−42	21	0.084 ± 0.184	−0.138 ± 0.147	<0.001
	L Postcentral	236	4.8	−21	−45	69	0.003 ± 0.129	−0.227 ± 0.163	<0.001
FC-Seed region-2	R Vermis	105	4.1	0	−51	−33	0.046 ± 0.104	−0.156 ± 0.181	<0.001
	R Precuneus	61	−4.6	18	−39	3	−0.147 ± 0.113	0.041 ± 0.130	<0.001
	L Middle Frontal	41	−3.9	−36	27	30	−0.112 ± 0.180	0.124 ± 0.233	0.001
FC-Seed region-3	R Middle Temporal	137	4.9	60	−33	−9	0.012 ± 0.125	−0.204 ± 0.134	<0.001
	R Superior Parietal	91	−4.2	24	−54	57	0.058 ± 0.201	0.299 ± 0.157	<0.001

L, Left; R, Right; ALFF, Amplitude of low frequency fluctuations; FC, functional connectivity.