Table 1.
Worm recovery and protection level in Sm29 immunized groups.
| Worm burden recovery | ||||||||
|---|---|---|---|---|---|---|---|---|
| Male Mean ±SD | Female Mean ±SD | Total Mean ±SD | % of protectionb | Egg/gram of liver Mean ±SD | % of reductionb | Egg/gram of intestine Mean ±SD | % of reductionb | |
| TRIAL 1a | ||||||||
| Challenge control | ||||||||
| ALUM | 17 ± 5 | 18 ± 4 | 35 ± 9 | ND | ND | |||
| Sm29 ALUM | 12 ± 4 | 12 ± 4 | 25 ± 8 | 29% (p = 0.03) | ND | ND | ||
| MPLA | 13 ± 6 | 15 ± 7 | 27 ± 12 | ND | ND | |||
| Sm29 MPLA | 13 ± 5 | 13 ± 6 | 26 ± 11 | 4% (NS) | ND | ND | ||
| TRIAL 2a | ||||||||
| Challenge control | ||||||||
| ALUM | 21 ± 4 | 20 ± 4 | 41 ± 8 | 14241 ± 2695 | 8900 ± 1894 | |||
| Sm29 ALUM | 15 ± 7 | 15 ± 9 | 26 ± 13 | 37% (p = 0.02) | 11004 ± 2776 | 23% (p = 0.04) | 9727 ± 5248 | (NS) |
| MPLA | 18 ± 8 | 20 ± 9 | 38 ± 16 | 10288 ± 2077 | 10400 ± 8712 | |||
| Sm29 MPLA | 18 ± 7 | 17 ± 8 | 34 ± 15 | 11% (NS) | 13665 + 3391 | 9860 ± 4813 | 5 % (NS) | |
| TRIAL 3a | ||||||||
| Challenge control | ||||||||
| ALUM | 20 ± 5 | 17 ± 4 | 38 ± 6 | 43285 ± 21394 | 8265 ± 1536 | |||
| Sm29 ALUM | 15 ± 5 | 13 ± 5 | 27 ± 10 | 29% (p = 0.04) | 22554 ± 5726 | 48% (p = 0.04) | 7594 ± 4287 | 8%(NS) |
| MPLA | 16 ± 5 | 15 ± 3 | 31 ± 8 | 58346 ± 28976 | 7568 ± 4768 | |||
| Sm29 MPLA | 14 + 6 | 15 + 7 | 33 + 10 | (NS) | 44069 ± 24010 | 24% (NS) | 12042 + 5743 | (NS) |
a
For each vaccinated group: n = 10 mice.
b
Comparison between total burden recovered from Sm29 ALUM or MPLA group and ALUM or MPLA control group.
NS, not significant.
ND, not determined.