Fig. 4.

T lymphocytes are not the source of IL-10 to induce resolution. a Il10 mRNA level in the meninges 72 h post-LPS (n = 6 mice per group). One-way ANOVA followed by Bonferroni’s correction (F(4,20) = 9.76, P = 0.0002). b The forced-swim test was performed 24 h and 72 h post-injection in Rag1^−/− mice reconstituted with WT or Il10^−/− T lymphocytes (n = 5 mice/group). Two-way ANOVA followed by Bonferroni’s correction (T lymphocytes genotype × time interaction, F(3,32) = 5.26, P = 0.005). c Ido1 mRNA level in the PFC 72 h post-LPS in Rag1^−/− mice reconstituted with WT or Il10^−/− T lymphocytes (n = 5 mice/group). d Il10 mRNA level in the PFC 72 h post-LPS in Rag1^−/− mice reconstituted with WT or Il10^−/− T lymphocytes (n = 5 mice/group). Two-way ANOVA followed by Bonferroni’s correction (LPS effect, F(1,16) = 9.75, P = 0.007). The data are presented as mean ± standard error of the mean. Significant effects of LPS are shown by * for Rag1^−/− mice reconstituted with WT and ^# for Il10^−/− T lymphocytes; ***P < 0.001, **P < 0.01, *^/#P < 0.05