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. 2018 Jul 6;37(45):5926–5938. doi: 10.1038/s41388-018-0394-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Trabectedin regulates mesenchymal markers expression in vitro and in vivo through HMGA1/E2F1 axis. a Total cell lysates and b mRNA levels from 402-91 WT and 402-91 ET cells were analyzed by WB and qRT-CR for the expression of HMGA1, E2F1, ZEB1, and Vimentin before and after trabectedin treatment. c Total cell lysates from ML017 PDX, responsive (#402, #434, and #438) and resistant (#319, #347, and #369) to trabectedin, were analyzed by WB for the expression of HMGA1, E2F1, ZEB1, and Vimentin. d Relative expression was quantified by ImageJ 1.47v using Hsp70 protein for normalization