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. 2018 Jul 6;37(45):5926–5938. doi: 10.1038/s41388-018-0394-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Trabectedin downregulates in vivo mesenchymal markers in MLS after neo-adjuvant chemotherapy. H&E sections and IHC analysis of HMGA1, E2F1, and vimentin in the bioptic sample of MLS tissues before therapy (a and c panels) and on the surgical sample obtained after trabectedin therapy (b and d panels). H&E sections and IHC analysis for the expression of HMGA1, E2F1, and vimentin of specimens derived from distant metastases of patient c whose tumor has progressed: superior limb metastasis (e), and parotid metastasis (f). (Scale bar = 30 μm)