Table 3.

Summary of logistic regression for reinduction failure for medullary disease at reporting TACL institutions (267 unique patients with 458 salvage attempts)

		Response		Univariable analysis		Multivariable analysis
Variable	Variable levels	CR	Failure	OR	95% CI	OR	95% CI
Salvage attempt	1	116	52	1.0	–	1.0	–
	2	84	81	2.15	1.37–3.36	1.83	1.12–2.99
	3 and over	43	82	4.25	2.60–6.96	3.02	1.72–5.31
	p-value			<0.0001		0.0004
	Trend p-value			<0.0001		0.0001
Duration of previous remission (CR)	CR not achieved	48	80	1.39	0.84–2.31	1.20	0.69–2.08
	CR achieved, < 18 m duration	56	67	1.0	–	1.0	–
	CR achieved, 18–36 m duration	52	19	0.31	0.16–0.56	0.37	0.19–0.71
	CR achieved, > 36 m duration	48	8	0.14	0.06–0.32	0.19	0.08–0.46
	Not evaluable for response	39	41	0.88	0.50–1.54	0.70	0.37–1.29
	p-value			<0.0001		<0.0001
	Trend p-value			0.0021		0.0028
NCI risk category at diagnosis	Non-infants, standard risk	110	63	1.0	–	1.0	–
	Non-infants, high risk	100	103	1.80	1.19–2.72	1.62	1.03–2.56
	Non-infants, unknown	23	31	2.35	1.26–4.38	1.80	0.90–3.60
	Infants	10	18	3.14	1.37–7.23	3.06	1.25–7.51
	p-value			0.0020		0.0322
Extramedullary involvement at start of therapy	No	194	171	1.0	–	1.0	–
	Yes	49	44	1.02	0.64–1.61	1.21	0.73–2.01
	p-value			0.9364		0.4499
BM status at start of therapy	M2	39	35	1.0	–	1.0	–
	M3	204	180	0.98	0.59–1.62	1.45	0.83–2.54
	p-value			0.9469		0.1916
Cytogenetics	Favorable	49	29	1.0	–	1.0	–
	Unfavorable	47	59	2.12	1.17–3.86	1.2	0.59–2.45
	Other	147	127	1.46	0.87–2.45	1.0	0.55–1.83
	p-value			0.0429		0.7991

BM bone marrow, CI confidence interval, CR complete remission, NCI National Cancer Institute, OR odds ratio. The bold values are the p-values with statstical significance (< 0.05)