Fig. 2.

SNVs at cis-regulatory elements affect gene expression in multiple myeloma. Mutations in the CRE significantly alter a PAX5 (n = 197 versus n = 13) and b ST6GAL1 (n = 315 versus n = 15) expression. Difference in expression was assessed pairwise by negative binomial test. *Q < 0.1, **Q < 0.05. The hinges of the boxplot indicate the first and third quartile range. c Chromatin looping interactions between PAX5 promoter and differentially expressed CRE. Also shown are the ChIP-seq signals and relative positions of SNVs