Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 8;8:16551. doi: 10.1038/s41598-018-34877-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Different effects of rapamycin analogues on neointimal hyperplasia in injured carotid arteries. (a) Representative histological images of balloon-injured rat carotid arteries. The injured arteries were treated with control vehicle (0.1% dimethyl sulfoxide in PBS, Cont) or everolimus (5 and 20 μM in PBS, Ever) or biolimus (20 μM in PBS, Bio) for 15 min. Data in the graph are means ± SEM of intima-to-media ratio (n = 5–6 rats per group, ^*P < 0.05, ^**P < 0.001 with one-way ANOVA). N.S., not significant (b,c) Immunofluorecence staining for Ki67 (b) or TUNEL assay (c) in the tissue sections of injured carotid arteries. Data in the graph are means ± SEM of the percentages of Ki67⁺ cells (b) or TUNEL⁺ apoptotic cells (c) versus DAPI-labelled total cells in the lesion (dashed lines). DAPI indicates nuclei. (n = 3, ^*P < 0.05, ^**P < 0.01 with Student’s t-test). N.S., not significant (d) Immunofluorescence staining of LC3B in the tissue sections of injured carotid arteries. The number of LC3B punta was counted in the marked lesions (dashed line). Data in the graph show means ± SD of total number of LC3B puncta (n = 3, ^*P < 0.05, ^**P < 0.01 with Student’s t-test). N.S., not significant. Representative images are shown.