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. 2018 Nov 8;8:16529. doi: 10.1038/s41598-018-33070-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Obeticholic acid increases biliary bile acid output in rats with obstructive cholestasis. Shown are total bile acid (BA) levels in plasma (A) and liver tissue (B), and bile collected from the extrahepatic bile duct before decompression and subsequent PHx (C–D). The total BA data for the control group and the untreated BDL group were published previously¹⁴. Data were obtained after seven days of BDL (i.e., prior to PHx). Abbreviations: rBDL = reversible bile duct ligation; OCA = obeticholic acid. ***Indicates p < 0.001 versus the control group. ^#Indicates p < 0.05 and ^###indicates p < 0.001 between the experimental groups indicated by the solid line. N = 4–6 per group per time point.