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Schematic diagram of post-translational regulation of p53 on targets. (a) p53 antagonizes ferroptosis by favoring DPP4 into a nuclear to form of the DPP4–p53 complex and impeding formation of the DPP4–NOX complex, which is required for lipid peroxidation in ferroptosis. (b) p53 suppresses glucose metabolism and production of NADPH via inhibiting glucose-6-phosphate dehydrogenase directly.
