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. 2018 Nov 2;9:1260. doi: 10.3389/fphar.2018.01260

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Copyright © 2018 Rezvantalab, Drude, Moraveji, Güvener, Koons, Shi, Lammers and Kiessling.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examples of actively targeted drug-loaded PLGA NPs. (A) Scheme of a magnetically and molecularly targeted stealth PLGA NP. (B) Tumor growth inhibition was most effective for HeLa xenografted mice treated with DTX-loaded Aptamer-poly(dopamine)-NPs (Apt-pD-NPs) compared to all control groups (NPs: DTX-loaded PLGA NPs; pD-NPs: poly(dopamine) coated-NPs; Apt-pD-NPs: AS1411 aptamer conjugated pD-NPs). Image republished with permission of Dove Medical Press Ltd., from Xu et al. (2016). (C) Tumor volume curves after withdrawing of the different drugs at day 40. Breast cancer tumor-bearing mice were treated with PBS, PLGA NPs, hyaluronic acid-cystamine-PLGA (HA-SS-PLGA), free DOX, DOX-loaded PLGA NPs, DOX-loaded HA-SS-PLGA, free cyclopamine (CYC), CYC-loaded PLGA NPs, CYC-loaded HA-SS-PLGA, DOX- and CYC-loaded PLGA, DOX-and CYC-loaded HA-SS-PLGA NPs. Drug-loaded PLGA-HA particles (HA-SS-PLGA-DOX, HA-SS-PLGA-CYC and HA-SS-PLGA-DOX-CYC) and dual-drug-loaded particles (PLGA-DOX-CYC and HA-SS- PLGA-DOX-CYC) significantly delayed tumor recurrence, while tumors rapidly regrew in case of treatments without CYC. Reproduced from Hu et al. (2015) with permission of The Royal Society of Chemistry. (D) Tumor growth curves (left) and survival rate (right) of colon carcinoma bearing mice treated with either SPIONs/PTX co-loaded PLGA NPs (PT), RGD grafted on PT NPs (RGD), PT NPs with 4 h magnetic targeting (MT), and RGD grafted on PT NPs with 4 h magnetic targeting (RGD + MT). Tumor growth curves show no significant difference between the groups solely treated with active or magnetic targeting, while the combination of both (CityRGD + MT) increased the survival rate significantly (^∗p < 0.05 and ^∗∗p < 0.01). Tumor growth curves (left) and survival rate (right) reprinted from Schleich et al. (2014) with permission from Elsevier.