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. 2018 Nov 2;9:1227. doi: 10.3389/fphar.2018.01227

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Copyright © 2018 Zhang, Zhang, Zhang, Zhang, Ye, Kuang, Sun and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NGR1 inhibits mitochondrial membrane depolarization and intracellular ROS in H9c2 cardiomyocytes induced by AGEs. (A,B) Representative images and bar graphs of JC-1 red/green cells and merges showed that NGR1 increased the ratio of red to green fluorescence intensity. (C) Intracellular ROS levels and statistical analysis. (D) in H9c2 cardiomyocytes evaluated using a flow cytometer, M1 represents ROS positive cell proportion. (E) Representative images of MitoSOX red staining. The bar represents 200 μm. (F) Immunoblotting analysis of Nrf2-mediated anti-oxidative enzymes in H9c2 cells. (G) The relative protein expression of Nucl-Nrf2, HO-1, γ-GCS, and NQO-1 compared to β-actin are expressed in the bar graphs. The quantitative data are presented as the mean ± SD of three independent experiments. ^##P < 0.01 vs. the Control group, ^∗P < 0.05 or ^∗∗P < 0.01 vs. the AGEs group.