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NGR1 attenuates diabetes-induced cardiac pathological alterations. (A,B) Reversal of diabetes-induced-cardiac hypertrophy and fibrosis by NGR1 as indicated by H&E and Masson staining (400×). (C) Representative images and bar graphs of TGFβ1 (D) and Collagen I (E) by western blot showed that NGR1 suppressed cardiac fibrosis. The quantitative data are presented as the mean ± SD (n = 3). ##P < 0.01 vs. the Control group, ∗P < 0.05 or ∗∗P < 0.01 vs. the Model group.
