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. 2018 Nov 2;9:1227. doi: 10.3389/fphar.2018.01227

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Copyright © 2018 Zhang, Zhang, Zhang, Zhang, Ye, Kuang, Sun and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NGR1 attenuates diabetes-induced myocardial apoptosis. (A) Representative images of apoptotic protein immunoblots and (B–D) immunoblotting results quantified in bar diagrams showing that NGR1 effectively inhibited diabetes-induced apoptosis. (E) Representative immunohistochemical images for cleaved caspase-3. The bar represents 20 μm. (F) NGR1 inhibited DNA injury in db/db mice as indicated by decreasing 8-OHdG levels. The quantitative data are presented as the mean ± SD (n = 3). ^##P < 0.01 vs. the Control group, ^∗P < 0.05 or ^∗∗P < 0.01 vs. the Model group.