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. 2018 Nov 2;12:802. doi: 10.3389/fnins.2018.00802

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Copyright © 2018 Xie, Zhou, Zhang, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection of ROS generation (A) and MDA production (B) in rat striatum. (A) Compared to the control group, over-generation of ROS was detected in the METH alone-treated rats, while the pretreatment with lactulose significantly decreased the ROS generation induced by METH. Significant compared to the control group (*p < 0.05); Significant compared to the METH alone-treated group (#p < 0.05). Lact, Lactulose. (B) Overproduction of MDA was observed in the METH alone-treated rats compared to the control group. The pretreatment with lactulose significantly suppressed the production of MDA resulting from the METH treatment. Significant compared to the control group (*p < 0.05); Significant compared to the METH alone-treated group (#p < 0.05). Lact, Lactulose.