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. 2018 Nov 2;12:802. doi: 10.3389/fnins.2018.00802

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Copyright © 2018 Xie, Zhou, Zhang, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RT-qPCR analysis for genes of Nrf2, HO-1, and p62 in rat striatum. Compared to the control group, mRNA expressions of Nrf2 and p62 were significantly up-regulated in the METH alone-treated rats, while no change of HO-1 was observed. The pretreatment with lactulose significantly increased mRNA expressions of Nrf2, HO-1 and p62 compared to the METH alone-treated rats. Significant compared to the control group (*p < 0.05); Significant compared to the METH alone-treated group (#p < 0.05). Lact, Lactulose.