Fig. 3.

Kaplan–Meier curves for HIF-1α-high and HIF-1α-low malignancies. The median survival time from tumour resection (t₀) to the first event (i.e., death, metastasis relapse) is depicted for a all malignant tumours (hazard ratio HIF-1α 2.31, 95% CI 1.19 −4.49), b squamous cell carcinoma, c lymphoma and d melanoma. Patients were dichotomised into a HIF-1α-high (defined as over the median value of HIF-1α-positive tumour cells, i.e.,  > 65% in SCCs, > 15% in lymphomas and > 13% melanomas) and a HIF-1α-low group ( < 65% in SCCs, < 15% in lymphomas and < 13% melanomas). Mean follow-up time was 7.2 years (SD 4.3) in the SCC, 8.8 years (SD 6.1) in the lymphoma and 7.1 years (SD 4.9) in the melanoma group. The number of patients at risk with HIF-1α-high and HIF-1α-low levels at 0, 5, 10 and 15 years following t0 are shown at the bottom of each plot