Table 4.
Effect of MCV change on the risk of specific causes of mortality.
| Variable | Model | CVD/CAD-related death | Cerebral ischemic stroke death | Cerebral hemorrhagic stroke death | Ischemic heart disease death |
|---|---|---|---|---|---|
| aHR (95% CI) | aHR (95% CI) | aHR (95% CI) | aHR (95% CI) | ||
| Difference in MCV (continuous) | Univariate | 1.02 (0.99–1.06) | 1.03 (0.93–1.15) | 1.06 (0.99–1.14) | 0.99 (0.94–1.05) |
| Multivariable* | 1.01 (0.97–1.05) | 1.06 (0.93–1.20) | 1.05 (0.97–1.14) | 0.98 (0.92–1.05) | |
| Difference in MCV ≥−0.5 vs. <−0.5 | Univariate | 1.36 (1.04–1.77) | 1.58 (0.68–3.65) | 1.96 (1.03–3.74) | 1.24 (0.82–1.86) |
| Multivariable* | 1.18 (0.90–1.54) | 1.56 (0.66–3.66) | 1.69 (0.88–3.25) | 1.12 (0.74–1.71) | |
| Change rate in MCV# (continuous) | Univariate | 1.03 (0.94–1.13) | 1.02 (0.77–1.36) | 1.09 (0.97–1.22) | 1.02 (0.88–1.19) |
| Multivariable* | 1.00 (0.91–1.10) | 1.05 (0.77–1.42) | 1.08 (0.91–1.28) | 1.01 (0.87–1.18) | |
| Change rate in MCV# ≥−0.13 vs. <−0.13 | Univariate | 1.37 (1.06–1.79) | 1.60 (0.69–3.70) | 1.99 (1.04–3.79) | 1.25 (0.83–1.89) |
| Multivariable* | 1.19 (0.91–1.55) | 1.58 (0.67–3.71) | 1.71 (0.89–3.29) | 1.13 (0.75–1.72) |
MCV: Mean corpuscular volume.
*Multivariable analysis adjusted for age, gender, and baseline MCV, and anemia.
#Change rate in MCV = difference in MCV/duration in years.