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. 2018 Nov 8;8:16584. doi: 10.1038/s41598-018-35027-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental design. Scheme (a) indicates the timing of the rotarod training and test, and the duration of the continuous spinal infusion of AMPA and TTC (grey horizontal bars). Black thin arrows indicate the timing of TTC i.m. injections before (TTC i.m. pre-treatment) or after (TTC i.m. post-treatment) surgery. The TrkA blocker GW-441756 was injected i.m. at the same time of TTC (co-administration, white arrows) or before TTC (pre- administration, blue arrows). All i.m. treatments were made bilaterally in both the gastrocnemius (G) and biceps femoris (BF) muscles shown in (b), as related to the infused (pink) and rostral (blue) regions of the spinal cord. These regions are intensively injured by AMPA and were analyzed separately by histology (Fig. 3b). The black dot represents the position of the probe in the spinal cord.