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. 2018 Nov 8;8:16579. doi: 10.1038/s41598-018-34938-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sequential administration of cetuximab after oxaliplatin reduces G1 arrest and enhances apoptosis. Cell cycle (A) and apoptosis (B) analyses of HCA7 cells subjected to different regimens containing 10 μg/ml cetuximab and/or 50 μM oxaliplatin: (1) control medium for 24 hours (white), (2) cetuximab for 24 hours (blue), (3) oxaliplatin for 24 hours (black), (4) simultaneous combination of oxaliplatin and cetuximab for 24 hours (grey), or treated sequentially (5) first with cetuximab for 24 hours followed by oxaliplatin for 24 hours (red) or (6) first with oxaliplatin for 24 hours followed by cetuximab for 24 hours (green). Cell cycle was analyzed by PI staining (A) and apoptosis by annexin V staining (B). Mean +/− SD is shown.