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. 2018 Nov 8;8:16519. doi: 10.1038/s41598-018-34879-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Surface proteins are required for exosomes to stimulate cardioprotection in Dys-iCMs. (a) Trypsinized Dys1-exos do not display exosomal surface markers, and (b) are intact and readily taken up into iCMs at 2 hr. (c) Exposure of Dys1-iCMs and (d) Dys3-iCMs to trypsinized exos failed to reduce ROS levels as significantly as intact exos. n = 3/group. *p < 0.05 vehicle stress vs. vehicle no stress, ^#p < 0.05 exosome exosome vs. vehicle stress, ^&p < 0.05 Trypsinized exosomes vs. intact exosomes, **p = 0.07 Trypsinized exosomes vs. intact exosomes.