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. 2018 Nov 8;8:16549. doi: 10.1038/s41598-018-34812-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The new L. donovani genome assembly results in a significant change in gene annotations. (a) New or improved gene annotations are highlighted in Blue along the 36 chromosomes. Compared to the previous L. donovani reference assembly (ASM22713v2 from strain BPK282A1), there were 1,087 protein coding genes unannotated or differently annotated in the current assembly. Unannotated or differently annotated genes were obtained by removing all annotations generated from our assembly that shared 95% or greater similarity to those previously available⁸. (b) Expansion of the amastin gene cluster on chromosome 8. Top track contains the previously two known coding sequences aligned to the previous L. donovani reference assembly (ASM22713v2 from strain BPK282A1). Gaps in the previous assembly depicted as dotted lines. Bottom track contains 10 amastin genes identified in the updated assembly. One previously identified Amastin gene has been aligned, 1 has been expanded and 8 have been annotated de novo.