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. 2018 Nov 8;9:4689. doi: 10.1038/s41467-018-07093-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — ScoMcrA-SBD undergoes conformational change upon recognition of PT-DNA. a In the PT-DNA-unbound state of ScoMcrA-SBD, the phenyl ring of the side-chain of ScoMcrA-Y164 covers the sulfur-binding cavity. b In the PT-DNA-bound state, the hydroxyphenyl group of Y164 is flipped open to allow the sulfur atom of PT-DNA to access the sulfur-binding cavity. c Comparing the PT-DNA-bound and PT-DNA-unbound states of ScoMcrA-SBD, the hydroxyphenyl group of Y164 is rotated 98° upon association of PT-DNA. d Association of PT-DNA also triggers a substantial conformational change of the “S¹⁸⁷RGRR¹⁹¹ loop” of ScoMcrA-SBD