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Twenty-eight-day Kaplan−Meier survival curves of low versus high proenkephalin A 119-159 (penkid) concentrations at admission, (a) based upon the cut-off value of 84.2 pmol/l (population median) in all patients from the Adrenomedullin and Outcome in Severe Sepsis and Septic Shock (AdrenOSS) study cohort, and (b) based upon the cut-off value of 85 pmol/l (population median) in all patients from the French and euRopean Outcome reGistry in Intensive Care Units (FROG-ICU) study cohort.
