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. 2018 Nov 1;23(5):700–713.e6. doi: 10.1016/j.stem.2018.10.004

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Screen for Chemoresistance in PPM1D Mutants

Various classes of chemotherapy agents were screened in the isogenic CRISPR-generated WT and PPM1D mutant cell lines (MOLM13, OCI-AML2, and OCI-AML3). The chemotherapy agents selected include key agents utilized in the treatment of primary tumors that t-AML/t-MDS patients in our cohort were previously exposed to. Dose response curves are shown, with red representing PPM1D mutants and gray representing WT. The data points represent mean ± SD of triplicates (n = 3).