Figure 2.

Peripheral blood proteins changed with combination therapy with sirolimus and hydroxychloroquine. Heat map of analytes that significantly changed during the treatment period for subjects with analyte measurements at baseline, the end of treatment (week 24), and the end of observation (week 48). Columns: individual patient measurements at weeks 0, 24, and 48; rows: analytes that changed significantly between weeks 0 and 24 by repeated measures analysis of variance. Log10-transformed analyte levels were scaled separately for each patient across the three visits of interest. Increased shades of yellow, increased relative to subject mean; increased shades of purple, decreased relative to subject mean; gray, unchanged relative to subject mean. Analytes were clustered hierarchically and subjects were clustered hierarchically and separately within each visit.