Table 7.
The inhibitory effect of all compounds on rabbit platelet aggregation induced by PAF (0.4 µg/mL)a
Compound | Concentration (µg/mL) | Inhibition (%)b |
---|---|---|
11 c | 900 | 84.9 ± 7.0 |
600 | 66.8 ± 3.9 | |
300 | 36.4 ± 3.1 | |
150 | 21.9 ± 6.6 | |
75 | 10.7 ± 8.5 | |
14 c | 800 | 68.1 ± 12.6 |
600 | 51.2 ± 12.7 | |
300 | 20.4 ± 7.1 | |
150 | 10.9 ± 0.6 | |
75 | 6.0 ± 2.6 | |
15 c | 900 | 73.3 ± 14.6 |
600 | 50.4 ± 6.7 | |
300 | 33.6 ± 5.1 | |
150 | 23.9 ± 9.6 | |
75 | 18.3 ± 7.4 | |
20 | 300 | 16.8 ± 6.7 |
25 | 300 | 17.0 ± 7.6 |
Ginkgolide Bd | 25 | 90.2 ± 10.4 |
12.5 | 56.9 ± 11.2 | |
6.25 | 33.9 ± 9.3 | |
3.125 | 19.5 ± 9.6 | |
1.5625 | 9.0 ± 5.2 |
aThe inhibition of other tested compounds (1–10, 12, 13, 16–19, 21–24, and 26–37) was less than 10% at the concentration of 300 µg/mL
bmean ± SD, n = 3
cThe IC50 values of 11, 14, and 15 was 470.3 ± 51.6 µg/mL, 614.9 ± 113.5 µg/mL, and 579.7 ± 139.1 µg/mL, respectively
dPositive control (IC50 = 12.2 ± 2.8 µg/mL)