TABLE 3.

Expression level of genes encoding transcription regulators, kinases and phosphatases, and cytokines and growth factors in m.vastus lateralis prior to, 4 h and 8 h after intensive cycling session (70 min, 70% ${\dot{\text{V}}\text{O}}_{2\max }$; n=2). Fold change was shown only for significantly (P_adj < 0.05) differentially expressed genes. Genes with supportive protein reliability in human skeletal muscle according to The Human Protein Atlas were marked: + detectable, n/d not detectable, n/a not available.

Official symbol	Expression level at rest, FPKM	4 h recovery		8 h recovery		Evidence at protein level according to The Human Protein Atlas
		Fold change, log2	Padj	Fold change, log2	Padj
Transcription regulators
ARNTL	0.34	1.6	3.68E-002	3.5	1.18E-017	+
ATOH8	1.48	1.2	2.98E-003			n/a
BHLHE41	18.66			-1.2	8.54E-004	+
CEBPB	34.76			-0.7	8.54E-004	+
CIART	6.86	-1.3	7.52E-005	-2.9	3.49E-018	n/d
CITED2	5.17			2.0	2.32E-008	+
DBP	2.56			-1.3	1.29E-003	+
ESRRG	0.98	3.4	9.78E-017	1.6	2.78E-002	+
FOS	1.11			-3.3	1.28E-009	+
FOXK1	1.19			1.0	2.50E-002	+
FOXO3	8.53			-1.2	9.74E-005	+
HDAC4	2.00			1.2	7.65E-004	+
HDAC9	1.18	-1.4	8.28E-006	-1.5	1.16E-006	+
HES1	11.25	-1.4	8.84E-003	-1.6	6.18E-003	+
HES4	4.56	1.8	2.13E-002			n/a
HSF2	16.48			-0.8	2.49E-003	n/d
JUNB	3.58	2.0	4.84E-006			+
JUND	19.28			-0.7	2.06E-002	n/d
KLF10	15.55			-1.3	2.15E-002	+
KLF13	6.89			-0.7	1.19E-002	+
KLF15	11.73	-0.8	2.64E-003	-0.8	3.53E-003	+
LDB2	2.11	-0.7	4.46E-002			+
MAFF	0.65	4.4	8.55E-026			n/d
MAFG	4.32			-1.0	1.41E-003	+
MNT	0.36	1.4	2.96E-002			n/a
NCOA3	3.38	-0.5	3.13E-002	-0.8	4.57E-004	+
NFIL3	3.44	1.3	4.19E-003	1.7	4.56E-006	n/d
NFKBIA	12.03	-0.5	2.14E-002			+
NR1D1	9.33	-1.4	3.02E-002			+
NR1D2	17.08	-0.9	2.06E-002	-1.3	7.69E-004	n/d
NR4A3	0.73	5.5	2.98E-003			+
PER1	14.15	-1.7	5.48E-015	-2.2	1.02E-024	+
PER2	1.95	-1.3	7.28E-004	-2.7	1.48E-012	+
PER3	3.23	-0.8	5.19E-003	-1.9	4.56E-012	+
PITX2	6.55	-0.5	3.38E-002			n/a
PLAGL2	2.02	-0.7	1.02E-002	-0.7	1.05E-002	+
PPARA	4.35			1.0	3.81E-002	+
PPARGC1A	5.73	2.8	1.39E-022			+
PPARGC1B	0.41	1.7	1.47E-006	1.5	6.00E-005	+
RAI1	0.49			1.5	1.25E-003	n/d
RARA	1.83	1.6	1.37E-003			+
RBM20	2.30	1.5	3.83E-005			+
RRN3	6.98			1.0	1.48E-002	+
SERTAD1	3.15	1.3	6.90E-003			n/a
SERTAD3	5.98			-0.6	2.71E-002	n/a
SOX6	1.07			-0.8	7.82E-005	+
SREBF1	1.77			1.2	3.70E-003	n/d
SS18L1	2.70			0.9	1.71E-002	+
TCF15	5.30	-1.1	2.55E-003			n/d
TEF	12.22			-0.8	6.73E-005	n/d
TLE1	10.73	-0.7	2.99E-004	-1.0	9.36E-008	+
TLE4	2.42			-0.7	1.05E-002	n/a
TRIM27	1.24			0.9	4.27E-002	+
VGLL2	34.22	1.4	2.97E-006			+
ZBTB16	4.25			-1.1	3.10E-003	n/d
ZC3H6	1.52	-0.6	1.41E-002	-0.6	1.58E-002	+
ZFP36	6.61			-1.1	1.11E-003	+
ZMIZ1	1.58	1.1	2.79E-004			n/d
ZNF493	0.23			1.4	2.95E-002	n/a
ZNF629	1.35			1.3	7.66E-005	n/d
ZNF827	0.70			1.3	1.32E-004	+
Kinases and phosphatases
ALPK3	23.22	1.2	1.17E-005	0.8	4.24E-002	+
CTDSP2	18.16	-0.4	2.00E-002			+
DUSP1	20.47	-0.9	9.60E-004	-1.2	2.03E-005	+
DUSP10	4.91	-0.6	4.86E-002			n/a
DUSP7	3.68			-0.9	8.28E-003	+
FAM20C	3.08	1.1	1.64E-003			+
FN3K	2.06	1.1	4.83E-002			+
HK2	4	1.6	4.61E-002			+
MAP3K14	1.33	1.4	5.82E-004			+
MKNK2	73.71	0.9	1.83E-002			+
PACSIN2	5.69	0.9	2.41E-002			n/d
PIK3R3	1.57	-0.6	4.23E-002			n/d
PPP1R16B	1.09	1.2	2.75E-002			n/d
PPP1R9B	2	1.2	1.67E-002			n/a
PPP2R3A	25.62			-0.4	1.71E-002	+
PPTC7	17.36	1	1.05E-003	1	1.32E-004	+
PRKAG2	1.1	5.1	4.33E-152	4.8	7.77E-135	+
PRKG1	9.9			-0.5	1.50E-002	+
SGK1	2.84			1.2	1.81E-002	+
SIK1	0.39	4.1	4.96E-004			+
SIK2	1.55	1.1	5.19E-003			+
SMG1	2.79	0.8	3.13E-002			+
TEK	2.9	1	1.54E-002			+
TRPM7	1.21	1.2	4.13E-003			+
Cytokines and growth factors
ANGPT2	0.29	2.3	1.55E-003			+
APLN	1.18	1.9	4.62E-003	2.1	4.00E-004	n/d
STC2	0.12	3.3	2.68E-007	2.3	9.14E-003	n/d
VEGFA	6.25	1.3	5.69E-003			+
WNT11	2.84			1.7	1.64E-004	+
WNT9A	1.47	2	4.54E-006			n/a