Table 2.
I. Type 1 (destruction of pancreatic β-cells, usually leading to absolute insulin deficiency) |
A. Autoimmune |
B. Idiopathic |
II. Type 2 (ranging from predominantly insulin secretory defect to predominantly insulin resistance with varying degrees of insulin secretory defect) |
III. Due to other specific mutation or diseases |
A. Those in which specific mutations have been identified as a cause of genetic susceptibility |
(1) Genetic abnormalities of pancreatic β-cell function |
(2) Genetic abnormalities of insulin action |
B. Those associated with other diseases or conditions |
(1) Diseases of exocrine pancreas |
(2) Endocrine disease |
(3) Liver disease |
(4) Drug- or chemical-induced |
(5) Infections |
(6) Rare forms of immune-mediated diabetes |
(7) Various genetic syndromes often associated with diabetes |
IV. Gestational diabetes mellitus |
The occurrence of diabetes specific complications has not been confirmed in some of these conditions. Those that cannot currently be classified as any of the above are considered unclassifiable