Table 5.
Details of blood lactic acid increase adverse events
| Basal therapy | Male/female | Age | AE start day | Metformin dose at AE start (mg/day) | Durationa (day) | Lactic acid level at baseline (mg/dl) | Creatinine lebel at baseline (mg/dl) | Lactic acid level at AE (mg/dl) | Creatinine level at AE (mg/dl) | Lactic acidosis symptomsb | Relation to metformin treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Monotherapy | Male | 55 | 78 | 1500 | 5 | 12.4 | 1.13 | 36.6 | 1.14 | No | No |
| Monotherapy | Male | 62 | 189 | 1500 | 29 | 6.2 | 0.69 | 23.0 | 0.64 | No | No |
| Monotherapy | Female | 39 | 343 | 2250 | 36 | 23.4 | 0.44 | 33.2 | 0.53 | No | Unknown |
AE adverse event
aFrom the AE start day to the day confirmed the outcome
bPotentially associated with lactic acidosis such as respiratory distress or increased drowsiness