Fig. 2.

Myeloid cell-specific SIRT1 deletion impairs glucose tolerance and insulin sensitivity in high-fat-fed mice. a, b Glucose concentration (a) and area under the curve of glucose concentration (b) in intraperitoneal glucose tolerance tests (ipGTT) for KO mice (n = 10) and control mice (n = 12). c Insulin concentration in ipGTT (n = 5). d, e Glucose levels shown as  % of basal value (d) and area over the curve of glucose levels (e) in intraperitoneal insulin tolerance tests (ipITT) for KO mice (n = 10) and control mice (n = 12). All experiments were performed after 6 weeks of HFD treatment. White triangles = fl/fl on HFD; black triangles = KO on HFD (a, c, d). Data are shown as the mean ± SEM; *P < 0.05