Table 2.
Changes in parameters before and after switching from sitagliptin to linagliptin
| At the initiation of sitagliptin | At 1 year before switching | At swiching | At 6 months after switching | At 1 year after switching | |
|---|---|---|---|---|---|
| BMI | 24.6 ± 5.0 | 24.6 ± 5.2 | 24.6 ± 4.1 | 23.8 ± 5.7 | 24.6 ± 4.1 |
| HbA1c (%) | 8.19 ± 1.07 | 7.39 ± 1.04†† | 7.32 ± 1.05†† | 7.44 ± 1.25†† | 7.46 ± 1.02†† |
| Systolic blood pressure (mmHg) | 132 ± 14 | 129 ± 17# | 128 ± 17# | 134 ± 15*** | 134 ± 15*** |
| Diastolic blood pressure (mmHg) | 72 ± 12 | 69 ± 12# | 68 ± 12† | 73 ± 10** | 71 ± 12* |
| Serum creatinine concentration (mg/dl) | 0.75 ± 0.25 | 0.79 ± 0.27# | 0.83 ± 0.32†† | 0.82 ± 0.32 | 0.84 ± 0.37 |
| eGFR (mi/min/1.73 m2) | 78.0 ± 24.4 | 74.2 ± 24.2# | 71.8 ± 23.3†† | 72.8 ± 23.9 | 72.3 ± 25.6 |
| Serum uric acid concentration (mg/dl) | 5.10 ± 1.13 | 5.34 ± 1.14# | 5.63 ± 1.24†† | 5.17 ± 1.04*** | 5.24 ± 1.10*** |
| Serum Na concentration (mEq/l) | 139.3 ± 2.4 | 139.8 ± 2.5 | 139.2 ± 2.4 | 140.3 ± 2.6 | 140.1 ± 2.8 |
| Serum K concentration (mEq/l) | 4.52 ± 0.35 | 4.47 ± 0.41 | 4.48 ± 0.56 | 4.54 ± 0.4 | 4.46 ± 0.4 |
Abbreviations are shown in the text. Repeated measures ANOVA with post hoc Bonferroni test. Data are expressed as mean ± SD
* P < 0.05, ** P < 0.01, *** P < 0.001 versus the value at switching from sitagliptin to linagliptin. # P < 0.05, † P < 0.01, †† P < 0.001 versus the value at the initiation of sitagliptin