Table 2.
Therapeutic effects of different drugs on kidney function indices in diabetic rats
| Groups | BUN (mg/dl) | Serum uric acid (mg/dl) | Serum creatinine (mg/dl) | Urine creatinine (mg/dl) | Creatinine clearance (ml/min) |
|---|---|---|---|---|---|
| Control | 26.48e ± 2.07 | 1.31d ± 0.070 | 0.42e ± 0.041 | 42.52a ± 8.91 | 1.26a ± 0.23 |
| Diabetic | 61.86a ± 2.02 (+133.00) | 3.89a ± 0.26 (+196.00) | 2.67a ± 0.18 (+535.00) | 13.86b ± 8.98 (−67.40) | 0.14c ± 0.04 (−88.40) |
| Treated (Rowatinex) | 28.36de ± 1.28 [−54.10] | 1.88c ± 0.13 [−51.60] | 0.75b ± 0.06 [−71.90] | 41.92a ± 6.28 [+202.00] | 0.83b ± 0.08 [+472.60] |
| Treated (melatonin) | 28.72cde ± 1.65 [−53.50] | 2.28b ± 0.24 [−41.20] | 0.508d ± 0.10 [−81.20] | 39.78a ± 7.56 [+187.00] | 0.84b ± 0.14 [+477.00] |
| Treated (Rowatinex + melatonin) | 30.84c ± 0.92 [−50.10] | 2.46b ± 0.12 [−36.70] | 0.552d ± 0.06 [−76.70] | 43.22a ± 6.63 [+211.00] | 0.90b ± 0.13 [+520.50] |
| LSP | 35.86b ± 1.78 [−42.00] | 1.89c ± 0.11 [−51.40] | 0.528d ± 0.06 [−80.50] | 39.90a ± 6.26 [+187.87] | 0.85b ± 0.15 [+485.00] |
| LSP + melatonin | 30.18cd ± 2.72 [−51.20] | 1.76c ± 0.09 [−54.70] | 0.642c ± 0.06 [−75.90] | 43.53a ± 7.98 [+214.00] | 0.84b ± 0.17 [+475.30] |
Data are mean ± SD of ten rats in each group
Statistical analysis was done using one-way analysis of variance (ANOVA) using the CoStat computer program accompanied by the least significance level (LSD) between groups at p < 0.05
Unshared superscript letters are significant values between groups at p < 0.0001
Values between brackets are % changes over the control group
Values between parentheses are % changes over the diabetic group