. 2016 Apr 11;7(4):413–424. doi: 10.1007/s13340-016-0268-9

Table 2.

Therapeutic effects of different drugs on kidney function indices in diabetic rats

Groups	BUN (mg/dl)	Serum uric acid (mg/dl)	Serum creatinine (mg/dl)	Urine creatinine (mg/dl)	Creatinine clearance (ml/min)
Control	26.48^e ± 2.07	1.31^d ± 0.070	0.42^e ± 0.041	42.52^a ± 8.91	1.26^a ± 0.23
Diabetic	61.86^a ± 2.02 (+133.00)	3.89^a ± 0.26 (+196.00)	2.67^a ± 0.18 (+535.00)	13.86^b ± 8.98 (−67.40)	0.14^c ± 0.04 (−88.40)
Treated (Rowatinex)	28.36^de ± 1.28 [−54.10]	1.88^c ± 0.13 [−51.60]	0.75^b ± 0.06 [−71.90]	41.92^a ± 6.28 [+202.00]	0.83^b ± 0.08 [+472.60]
Treated (melatonin)	28.72^cde ± 1.65 [−53.50]	2.28^b ± 0.24 [−41.20]	0.508^d ± 0.10 [−81.20]	39.78^a ± 7.56 [+187.00]	0.84^b ± 0.14 [+477.00]
Treated (Rowatinex + melatonin)	30.84^c ± 0.92 [−50.10]	2.46^b ± 0.12 [−36.70]	0.552^d ± 0.06 [−76.70]	43.22^a ± 6.63 [+211.00]	0.90^b ± 0.13 [+520.50]
LSP	35.86^b ± 1.78 [−42.00]	1.89^c ± 0.11 [−51.40]	0.528^d ± 0.06 [−80.50]	39.90^a ± 6.26 [+187.87]	0.85^b ± 0.15 [+485.00]
LSP + melatonin	30.18^cd ± 2.72 [−51.20]	1.76^c ± 0.09 [−54.70]	0.642^c ± 0.06 [−75.90]	43.53^a ± 7.98 [+214.00]	0.84^b ± 0.17 [+475.30]

Data are mean ± SD of ten rats in each group

Statistical analysis was done using one-way analysis of variance (ANOVA) using the CoStat computer program accompanied by the least significance level (LSD) between groups at p < 0.05

Unshared superscript letters are significant values between groups at p < 0.0001

Values between brackets are % changes over the control group

Values between parentheses are % changes over the diabetic group