Table 3.
Therapeutic effects of different drugs on oxidative stress markers in diabetic rats
| Groups | NO (µmol/g tissue) | MDA (µg/mg protein) | SOD (µg/mg protein) | GSH (µg/mg protein) | TAC (mM/l) |
|---|---|---|---|---|---|
| Control | 39.18f ± 3.95 | 70.68d ± 2.89 | 0.82a ± 0.07 | 2.21a ± 0.12 | 2.26a ± 0.17 |
| Diabetic | 88.92a ± 6.59 (+127.00) | 109.65a ± 7.50 (+55.20) | 0.53d ± 0.06 (−35.00) | 1.52e ± 0.057 (−31.00) | 1.21e ± 0.06 (−46.40) |
| Treated (Rowatinex) | 66.24b ± 6.19 [−25.50] | 87.04c ± 5.9 [−20.60] | 0.68a ± 0.06 [+27.00] | 1.78c ± 0.12 [+16.60] | 2.02b ± 0.12 [+67.00] |
| Treated (melatonin) | 55.60c ± 5.65 [−37.47] | 92.66b ± 5.48 [−15.50] | 0.71c ± 0.07 [+32.50] | 1.64d ± 0.05 [+7.60] | 1.96bc ± 0.11 [+62.50] |
| Treated (Rowatinex + melatonin) | 58.8c ± 6.23 [−34.00] | 90.06bc ± 9.96 [−18.00] | 0.71c ± 0.13 [+32.40] | 2.04b ± 0.16 [+34.00] | 2.04b ± 0.14 [+68.50] |
| LSP | 49.16g ± 3.85 [−44.70] | 90.98bc ± 8.13 [−17.00] | 0.766b ± 0.06 [+43.00] | 1.85c ± 0.28 [+21.75] | 1.90c ± 0.14 [+57.00] |
| LSP + melatonin | 43.52e ± 0.84 [−51.00] | 86.84c ± 7.38 [−21.00] | 0.72bc ± 0.11 [+35.50] | 2.00b ± 0.14 [+31.00] | 1.77d ± 0.16 [+46.00] |
Data are mean ± SD of ten rats in each group
Statistical analysis was done using one-way analysis of variance (ANOVA) using the CoStat computer program accompanied by the least significance level (LSD) between groups at p < 0.05
Unshared superscript letters are significant values between groups at p < 0.0001
Values between brackets are % changes over the control group
Values between parentheses are % changes over the diabetic group