Table 4.

Multivariable-adjusted ORs for MCI assessed using the mini-mental state examination according to years since quitting

	Never-smokers	Ex-smokers			p for trend
		≥20 years	10–19 years	≤9 years
MCI (%) (case/n)	16.4 (22/134)	18.0 (9/50)	21.6 (8/37)	31.9 (15/47)
OR (95 % CI) for MCI
Model 1	1.0	1.85 (0.58–5.88)	2.28 (0.72–7.23)	4.28 (1.59–11.38)	0.003
Model 2	1.0	2.02 (0.58–6.90)	2.67 (0.77–9.30)	5.09 (1.67–15.52)	0.004

Logistic regression analysis was used to estimate the adjusted ORs and 95 % CIs

Model 1: adjusted for age and sex

Model 2: adjusted for age, sex, systolic blood pressure, body mass index, HDL cholesterol, eGFR, HbA1c, insulin therapy (yes or no), sulfonylurea (yes or no), history of coronary heart disease (yes or no), exercise habit (≥2 times/week or <2 times/week), drinking status (never-, ex-, or current drinker), and education

MCI mild cognitive impairment, OR odds ratio, CI confidence interval, HDL high-density lipoprotein, eGFR estimated glomerular filtration rate, HbA1c hemoglobin A1c