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Selectivity of compound 1 and 5 against a panel of kinases (% enzyme activity relative to DMSO controls).
| Kinase 1 | 1 | 5 | ||
|---|---|---|---|---|
| Data 1 | Data 2 | Data 1 | Data 2 | |
| AKT1 | 110.03 | 105.00 | 106.92 | 105.28 |
| MNK1 | 3.64 | 2.53 | 115.13 | 111.38 |
| MNK2 | 1.87 | 0.79 | 97.56 | 96.04 |
| P38a/MAPK14 | 125.49 | 119.86 | 126.41 | 125.76 |
| PIM1 | 43.11 | 42.99 | 118.37 | 117.26 |
1 Compounds were tested in single dose duplicates at 1 μM and reactions were carried out at 10 µM ATP (Reaction Biology Kinase HotSpot Screening).
