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. 2018 Sep 12;23(9):2334. doi: 10.3390/molecules23092334

Figure 2.

Figure 2

Molecular mechanisms of EGCG inhibiting angiogenesis. EGCG down-regulated the expressions of HIF-1, E7 and EGF, resulting in VEGF down-regulation through AKT/PI3K/mTOR signaling pathways. The decline of VEGF could inhibit angiogenesis (a broken line means indirect approach). AKT: protein kinase B; E7: another HPV oncogene; EGF: epidermal growth factor; HIF-1: hypoxia-inducible factor 1; mTOR: mammalian target of rapamycin; PI3K: phosphoinositide-3-kinase; VEGF: vascular endothelial growth factor.