Table 2.
Cytotoxic activities of EGCG on human cervical cancer cell lines.
| Cell Line | Function | Cytotoxic Action | Reference |
|---|---|---|---|
| HeLa | Anti-proliferation | Induced G1 phase cell cycle arrest and apoptosis, inhibited EGFR signaling pathway | Sah et al. (2004) |
| Induced G2/M phase cell cycle arrest and apoptosis, depolymerized microtubule | Chakrabarty et al. (2011) | ||
| Reduced IGF-1R activity and inhibited proliferation of cells | Li et al. (2007) | ||
| Inhibited Akt and NF-kB activation, inhibited cell growth | Singh et al. (2011) | ||
| Inhibited the expression of Brf1, Brf2 and its promoter, inhibited RNA polIII transcription | Jacob et al. (2007) | ||
| Depolymerized cellular microtubule | Chakrabarty et al. (2015) | ||
| Inhibited HIF-1α protein accumulation, decreased VEGF expression, blocked P3K/Akt, ERK1/2 signaling pathway | Zhang et al. (2006) | ||
| Inhibited HPV E6, E7, ERα, and aromatase expression | Qiao et al. (2009) | ||
| Inhibited proteasome functionality, induced apoptosis | Bonfili et al. (2011) | ||
| Reduced enzymatic activity of DNMT and HDAC, inhibited carcinogenesis | Khan et al. (2015) | ||
| Anti-metastasis | Inhibited invasion and migration, decreased MMP-9 and TIMP-1 expression | Sharma et al. (2012) | |
| Reduced proliferation, adhesion, invasion of tumor cell, exhibited anti-angiogenesis effect | Tudoran et al. (2012) | ||
| Inhibited invasion and migration, decreased MMP-2, -9 expression | Roomi et al. (2010) | ||
| Pro-apoptosis | Inactivated Trx/TrxR, induced prooxidant cytotoxicity and apoptosis | Zhang et al. (2010) | |
| Induced LMP secretion | Zhang et al. (2012) | ||
| Induced formation of intracellular ROS | Krstic et al. (2015) | ||
| Caski | Anti-proliferation | Induced G1 phase cell cycle arrest and apoptosis, regulated gene expression | Ahn et al. (2003) |
| Induced G1 phase cell cycle arrest and apoptosis, inhibited EGFR signaling pathway | Sah et al. (2004) | ||
| Inhibited HPV E6/7, ERα, and aromatase expression | Qiao et al. (2009) | ||
| SiHa | Anti-proliferation | Induced G1 phase cell cycle arrest and apoptosis, inhibited EGFR signaling pathway | Sah et al. (2004) |
| Pro-apoptosis | Increased caspase-3, -8, -9 secretion and inhibited cell growth | Al-Hazzani et al. (2011) | |
| OMC-1 | Anti-proliferation | Inhibited telomerase activity, induced cell cycle dysregulation and apoptosis | Noguchi et al. 2006) |
| HEN, HEC | Anti-proliferation | Inhibited telomerase activity and cell growth, induced apoptosis | Yokoyama et al. (2004) |