Skip to main content
. 2018 Aug 28;23(9):2162. doi: 10.3390/molecules23092162

Scheme 1.

Scheme 1

Synthetic protocol developed for the preparation of the penta-heterocyclic compounds: (A) one-step synthetic pathway followed for the preparation of compounds 14; and (B) multi-step synthetic pathway for the preparation of compound 5 (a) 1,1’-carbonyldiimidazole (CDI), dry DMF, 16 h, r.t.; (b) 1,1’-carbonyldiimidazole (CDI), dry DMF, 6 h, 150 °C; and (c) NH2OH/Na2CO3, H2O, 1 h, r.t.).