Table 1.
Relevant metabolites derived from the pairwise OPLS-DA models of 1H-NMR analysis of aqueous extracts between controls and Ptac2S and cisplatin treated samples. Positive (+) and negative (−) sign indicate positive and negative correlation in the concentration, respectively.
| Metabolites | δ(1H)/ppm | Ptac2S/Controls | Cisplatin/Controls | Ptac2S/Cisplatin | |||
|---|---|---|---|---|---|---|---|
| 6 h | 24 h | 6 h | 24 h | 6 h | 24 h | ||
| Acetate | 1.94(s) | − | − | − | − | + | |
| Alanine | 1.48(d); 3.80(m) | − | − | − | |||
| AMP | 8.23(s); 8.56(s) | − | − | − | − | ||
| Cho | 3.21(s) | + | − | + | |||
| Creatine | 3.05(s); 3.93(s) | − | − | + | − | − | + |
| Dimethylamine | 2.74(s) | − | + | − | + | − | + |
| Formate | 8.46 | − | − | ||||
| GPC | 3.24(s) | − | |||||
| Glycerol | 3.65(m) | + | + | + | + | ||
| Glycine | 3.56(s) | − | − | − | − | − | |
| Glutamine | 2.15(m); 2.45(m); 3.77(m) | − | − | − | − | − | − |
| Glutamate | 2.05(m); 2.12(m); 2.35(m) | − | − | − | − | − | − |
| Lactate | 1.32(d); 4.11(q) | − | − | − | − | + | + |
| m-inositol | 3.25(t); 3.54(dd); 3.62(t); 4.05(t) | − | − | − | |||
| Isoleucine | 0.94(t); 1.01(d); 1.98(m) | − | − | + | |||
| Leucine | 0.96(d); 0.97(d); 1.72(m); 1.73 (m) | − | + | ||||
| PC | 3.23(s) | − | − | + | − | − | + |
| Pyruvate | 2.38(s) | − | + | ||||
| Serine | 3.84(dd); 3.95(dd); 3.98(dd) | + | + | + | + | ||
| Succinate | 2.41(s) | − | − | − | − | + | |
| Taurine | 3.25(t); 3.43(t) | − | − | − | − | − | |
| TMAO | 2.9(s) | + | |||||
| UDP-Glucose | 5.97(d); 5.61(m); 6.10(d); 7.93(d) | − | − | ||||
| Valine | 1.00(d); 1.05(d); 2.28(m); 3.62(d) | − | + | ||||