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. 2018 Aug 30;23(9):2186. doi: 10.3390/molecules23092186

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The direct negative inotropic effect of CPA in the presence of NBTI, without and with a previous FSCPX pre-treatment. The applied (pre)treatments and experimental groups (latter ones in italics) are indicated. The x-axis denotes the common logarithm of the molar CPA concentration (in the bathing medium) and the y-axis indicates the effect (as a percentage decrease in the initial contractile force). The symbols show the responses to CPA averaged within the groups (±SEM) and the dotted curves illustrate the fitted model of RRM (Equation (2)). CPA: N⁶-cyclopentyladenosine; NBTI: S-(2-hydroxy-5-nitrobenzyl)-6-thioinosine; FSCPX: 8-cyclopentyl-N³-[3-(4-(fluorosulfonyl)benzoyloxy)propyl]-N¹-propylxanthine.