Table 2.
Cell viability and inhibitory activities of extracts and isolated compounds. PTP1B, protein tyrosine phosphatase 1B.
| Compound | Cell Viability | PTP1B | α-Glucosidase |
|---|---|---|---|
| % of Control a | IC50 | IC50 | |
| 1 | 50.49 ± 1.68 | 80.19 ± 5.28 b | 60.52 ± 4.19 b |
| 2 | 81.52 ± 2.66 | 5.56 ± 0.38 b | 8.59 ± 1.52 b |
| 3 | 56.22 ± 3.98 | 24.89 ± 2.39 b | 30.06 ± 3.19 b |
| 4 | 59.27 ± 4.83 | 20.56 ± 2.01 b | 25.33 ± 5.19 b |
| 5 | 55.13 ± 2.78 | 82.87 ± 8.61 b | 53.98 ± 3.09 b |
| 6 | 57.19 ± 4.68 | 81.59 ± 7.09 b | 52.09 ± 4.65 b |
| 7 | 55.21 ± 3.19 | 98.01 ± 8.21 b | 59.11 ± 5.06 b |
| 8 | 59.98 ± 4.61 | 70.52 ± 5.25 b | 49.37 ± 5.21 b |
| 9 | 58.99 ± 3.68 | 78.42 ± 6.15 b | 52.17 ± 5.91 b |
| 10 | 53.29 ± 2.76 | 89.56 ± 7.06 b | 69.38 ± 5.81 b |
| 11 | 65.35 ± 5.35 | 4.16 ± 0.56 b | 1.61 ± 0.06 b |
| 12 | 63.77 ± 4.15 | 3.92 ± 0.36 b | 2.73 ± 0.33 b |
| 13 | 67.29 ± 3.16 | 3.53 ± 0.92 b | 0.52 ± 0.09 b |
| 14 | 70.17 ± 3.26 | >100 b | >100 b |
| 15 | 69.71 ± 3.07 | 9.58 ± 1.82 b | 7.56 ± 1.99 b |
| 16 | 63.29 ± 3.18 | 15.38 ± 2.76 b | 10.96 ± 1.78 b |
| 17 | 72.27 ± 4.69 | 20.16 ± 3.02 b | 15.28 ± 1.77 b |
| 18 | 57.66 ± 4.56 | 51.11 ± 5.92 b | 63.93 ± 5.12 b |
| 19 | 68.51 ± 3.78 | 1.03 ± 0.12 b | 9.45 ± 1.62 b |
| 20 | 53.26 ± 4.13 | 81.16 ± 7.39 b | 45.08 ± 3.52 b |
| 21 | 49.79 ± 3.98 | >100 b | >100 b |
| 22 | 55.49 ± 4.49 | 79.07 ± 7.99 b | 43.58 ± 5.09 b |
| 23 | 51.22 ± 3.10 | >100 b | >100 b |
| 24 | 50.62 ± 2.91 | >100 b | >100 b |
| 25 | 52.56 ± 3.58 | 50.19 ± 6.01 b | 60.09 ± 5.29 b |
| 26 | 52.96 ± 2.86 | 70.99 ± 7.19 b | 90.89 ± 9.69 b |
| 75% EtOH extract | 64.16 ± 5.06 | 40.16 ± 4.53 c | 15.63 ± 2.11 c |
| Na3VO4 | – | 28.91 ± 2.78 b 5.32 ± 0.51 c |
|
| Acarbose | – | 5.90 ± 0.98 b 3.81 ± 0.63 c |
a Cell protection rate of the compounds (100 μM) and the extract (100 μg/mL) on H2O2-treated MIN6 cells. b μM. c μg/mL.